For most people I teach, like 95%, this particular rhythm pattern comes off as very challenging. Making sure to tap your foot only the down beats, and really feeling and counting this rhythm as it's written can feel really weird for most people.
The pattern of 16th to 8th note is repeated over and over again, which lasts 3 full bars. The 4th bar is something different to break things up before the chord progression repeats, and the weirdness begins again.
Here are two ways to look at the count for all 4 bars:
Here is the Guitar Pro 6 tab for this lesson:
John Taylor - guitar and bass instructor for Mile High Shred.